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Oxandrolone Wikipedia

Contents

Oxandrolone

Medical uses

Non-medical uses

Contraindications

Side effects

Drug-drug interactions

Pharmacology

Pharmacodynamics

Steroid configuration

Pharmacokinetics

Chemistry

History

Society and culture

Generic names

Brand names

Availability

United States

Other countries

Legal status

References

External links

Oxandrolone

Oxandrolone is a synthetic anabolic–androgenic steroid
(AAS) derived from dihydrotestosterone. It was first synthesized
in the 1960s by the pharmaceutical company Searle Laboratories as part of research into more selective and less androgenic steroids for therapeutic
use. The compound is known chemically as 2,4-androstadien-17β-ol-3-one.

Medical uses

Oxandrolone is approved primarily for its anabolic properties to promote weight
gain in patients experiencing severe burns, chronic infections,
or significant muscle loss due to disease. It is also prescribed to treat osteoporosis by increasing bone density and as a
supplement in the management of hormone deficiencies such as hypogonadism.
In some cases, it aids recovery after major surgeries or trauma.

Non-medical uses

Athletes and bodybuilders often use oxandrolone for its muscle-building
capabilities while minimizing estrogenic side effects.
It is popular for cutting cycles to help preserve lean mass during calorie restriction. Additionally, the steroid is sometimes used by individuals
seeking enhanced physical performance or improved endurance,
despite lacking official medical endorsement for these
purposes.

Contraindications

Oxandrolone should not be taken by patients with liver disease, as it undergoes hepatic metabolism and can exacerbate hepatic dysfunction. It is also contraindicated in individuals with
breast or prostate cancer, uncontrolled hypertension,
or a history of thromboembolic events. Pregnant or lactating women must avoid the drug due to potential
fetal harm.

Side effects

Common adverse reactions include elevated liver enzymes, altered lipid profiles (increased LDL and decreased
HDL), acne, hair loss, and mood changes such as aggression or depression. In men, gynecomastia can occur
if estrogenic metabolites accumulate, though this is less frequent
than with other steroids. Women may experience virilization symptoms like deepening
of the voice or hirsutism. Long-term use can lead to suppression of natural testosterone production and testicular
atrophy.

Drug-drug interactions

Oxandrolone may interact with anticoagulants by affecting platelet
function, potentially increasing bleeding risk.

Concurrent use with other hepatotoxic medications
can amplify liver injury. It also interacts with medications that influence lipid metabolism, such as statins,
possibly necessitating dose adjustments or monitoring of cholesterol levels.

Pharmacology

The drug exhibits both anabolic and androgenic activity, promoting protein synthesis in muscle tissue
while exerting relatively mild masculinizing effects compared to other AAS.
Its selective action on anabolic pathways makes it useful for weight gain without
severe androgenic side effects.

Pharmacodynamics

Oxandrolone binds to the androgen receptor with moderate affinity, triggering transcription of genes involved in muscle growth and bone
formation. It also inhibits protein catabolism by suppressing cortisol-mediated
breakdown pathways. The drug’s half-life allows for once-daily
dosing, facilitating consistent therapeutic levels.

Steroid configuration

The molecule features a 19-carbon backbone characteristic of steroids,
with double bonds at the 2-3 and 4-5 positions (Δ^2,
4). It lacks a 17α-hydroxyl group, reducing androgenic potency while maintaining anabolic activity.
The 17β-hydroxy group contributes to its binding affinity for the androgen receptor.

Pharmacokinetics

After oral administration, oxandrolone is absorbed rapidly with peak plasma concentrations reached within 2–3 hours.
It undergoes extensive first-pass hepatic metabolism, primarily via reduction and conjugation pathways, leading to metabolites excreted
in urine. The elimination half-life ranges from 9 to 12 hours, allowing for twice-daily dosing if higher
therapeutic levels are required.

Chemistry

Oxandrolone is a C19 steroid with the formula C18H24O2.

It is structurally related to testosterone but modified at positions that reduce androgenic activity
while preserving anabolic effects. The presence of double
bonds increases metabolic stability, contributing to its
oral bioavailability.

History

The development of oxandrolone in the 1960s marked a shift toward creating
steroids with favorable safety profiles for medical use.

Its first approval by the FDA came in 1975 under the brand name Anavar for weight loss
and muscle wasting conditions. Over subsequent decades, research expanded its applications
to osteoporosis and post-operative recovery.

Society and culture

Despite its legitimate therapeutic uses, oxandrolone has
gained notoriety within sports communities due to its performance-enhancing potential.

The steroid is frequently found on lists of banned substances in professional athletics.
Public perception often conflates medical use with illicit doping, leading to stigma among
patients who require the drug for health reasons.

Generic names

The International Nonproprietary Name (INN) for oxandrolone remains the same: oxandrolone.

Brand names

Common brand names include anavar dosage bodybuilding and Oxynorm.
These trademarks vary by region but represent the same active ingredient.

Availability

Oxandrolone is available in tablet form, typically 2.5
mg or 10 mg strengths. Availability depends on regulatory approval and prescription status within each
country.

United States

In the United States, oxandrolone is classified as a Schedule III controlled substance under the Controlled Substances
Act, indicating a recognized medical use but potential for abuse.
Prescriptions are limited to specific indications such as severe
weight loss or bone density improvement.

Other countries

Outside the U.S., oxandrolone is also regulated as a prescription medication in many nations, though legal classification varies.

Some countries may list it under broader anabolic
steroid regulations, limiting over-the-counter access and requiring medical oversight.

Legal status

Globally, oxandrolone falls under drug control laws that restrict non-medical use due
to its potential for performance enhancement and health risks.
Sports governing bodies prohibit possession or use without a
valid prescription, enforcing anti-doping rules.

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Long‑term stimulation of growth hormone release can indirectly affect other hormones such as insulin, cortisol, prolactin, and sex steroids. Elevated growth hormone levels have been associated with increased insulin resistance, which in turn raises the risk for type 2 diabetes mellitus. In some cases, users report menstrual irregularities or changes in libido due to altered sex hormone dynamics.

Metabolic Consequences

Sustained high levels of growth hormone can influence lipid metabolism, potentially leading to dyslipidemia. Elevated triglycerides and low HDL cholesterol have been observed in certain long‑term studies, increasing cardiovascular risk over time. Additionally, chronic use may alter bone remodeling processes; while growth hormone promotes bone density, excessive stimulation could paradoxically impair mineralization or lead to osteomalacia.

Cardiovascular Impact

Growth hormone excess is linked with hypertension and left ventricular hypertrophy. Although ipamorelin’s potency is lower than other ghrelin mimetics, prolonged use may still elevate blood pressure in susceptible individuals. Regular cardiovascular assessment is recommended for users on long‑term therapy.

Immune System Modulation

Growth hormone can modulate immune function by influencing cytokine production and lymphocyte activity. Long‑term elevation might predispose to autoimmune reactions or alter the body’s response to infections. Some reports suggest an increased incidence of allergic reactions or eczema in chronic users, though data remain limited.

Psychological Effects

Hormonal changes may influence mood, cognition, and sleep patterns. Users have noted episodes of irritability, anxiety, or mild depression when on prolonged ipamorelin regimens. These effects appear to correlate with peaks in growth hormone secretion, underscoring the need for psychological monitoring.

Injection Site Complications

Repeated intramuscular injections can lead to local tissue changes such as fibrosis, granuloma formation, or chronic pain. In rare cases, infection or abscess may develop if injection technique is suboptimal.

Hormone Therapy

When ipamorelin is incorporated into a broader hormone therapy protocol—often alongside selective estrogen receptor modulators, anabolic steroids, or testosterone replacement—the risk profile changes. The additive effect on growth hormone and insulin‑like growth factor 1 (IGF‑1) can magnify the metabolic side effects described above. Furthermore, combined therapies may exacerbate cardiovascular strain, particularly in older adults or those with pre‑existing heart disease.

Patients undergoing long‑term ipamorelin therapy should therefore receive comprehensive endocrine evaluation at baseline and periodically thereafter. This includes serum measurements of growth hormone, IGF‑1, insulin, cortisol, sex steroids, thyroid hormones, and lipid panels. Imaging studies such as echocardiograms or bone density scans may be warranted if clinical symptoms arise.

FAQs: Ipamorelin Side Effects

Q: How long does it take for side effects to appear?

A: Mild reactions often surface within the first week of use, while metabolic changes typically become apparent after several months of continuous therapy.

Q: Can I stop ipamorelin if I notice side effects?

A: Abrupt cessation may lead to withdrawal symptoms such as fatigue or mood disturbances due to sudden drops in growth hormone levels. Gradual tapering under medical supervision is recommended.

Q: Are there specific populations at higher risk?

A: Individuals with pre‑existing diabetes, hypertension, liver disease, or hormonal disorders should exercise caution and consult a healthcare professional before initiating therapy.

Q: Does ipamorelin interact with other medications?

A: Yes. It may interfere with antidiabetic drugs, antihypertensives, and hormone replacement therapies by altering their efficacy or side‑effect profiles.

Q: Is there evidence of cancer risk associated with long‑term use?

A: While growth hormone can stimulate cell proliferation, current data do not conclusively link ipamorelin to increased tumor incidence. Nonetheless, vigilant screening for malignancies is prudent in long‑term users.

In summary, while ipamorelin offers notable benefits for muscle anabolism and recovery, its long‑term side effect profile warrants a cautious approach. Regular monitoring of hormonal levels, metabolic parameters, cardiovascular health, and psychological well-being can help mitigate risks and ensure safe use over extended periods.

References:

https://www.valley.md/understanding-ipamorelin-side-effects

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